The possibilities are endless for the designs. If you need a robust site or a simple one, you have the choices with these new generations. While you may have to tweak code to work for you, you no longer need to write additional code over and above what is already there.
i3dtHEMES has done a superb job of annotating every section and sub-sections so you know what is going on within the code.
We've attempted some radical changes which some work and some not so good. So, as the norm, you can experiment. Just be sure you annotate your changes and keep plenty of backups just in case you have to start over.